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"Rogers, Kara"
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Skin and connective tissue
Examines the skin and connective tissues, looking at the general anatomy, biodynamics, and diseases of each.
Book
quiet extinction
\"The Quiet Extinction explores the reasons many of our native plants are disappearing, noting their significance to the continent's natural heritage. Kara Rogers captures the excitement of their discovery, the tragedy that has come to define their existence, and the remarkable efforts underway to save them\"--
eBook
Out of Nature
About half of all species under threat of extinction in the world today are plants. The loss of plant biodiversity is disturbing for many reasons, but especially because it is a reflection of the growing disconnect between humans and nature. Plants have been used for millennia in traditional systems of healing and have held a significant place in drug development for Western medicine as well. Despite the recent dominance of synthetic drug production, natural product discovery remains the backbone of drug development. As the diversity of life on Earth is depleted and increasing numbers of species become lost to extinction, we continue to lose opportunities to achieve advances in medicine.Through stories of drug revelation in nature and forays into botany, human behavior, and conservation, Kara Rogers sheds light on the multiple ways in which humans, medicine, and plants are interconnected. With accessible and engaging writing, she explores the relationships between humans and plants, relating the stories of plant hunters of centuries past and examining the impact of human activities on the environment and the world's biodiversity. Rogers also highlights the role that plant-based products can play in encouraging conservation and protecting the heritage and knowledge of indigenous peoples.Out of Natureprovides a fresh perspective on modern drug innovation and its relationship with nature. The book delves into the complexity of biophilia--the innate human attraction to life in the natural world--and suggests that the reawakening of this drive is fundamental to expanding conservation efforts and improving medicine. Rogers's examination of plants, humans, and drug discovery also conveys a passionate optimism for the future of biodiversity and medicine. Including a collection of hand-drawn maps and plant illustrations created by the author, this well-researched narrative will inspire as well as inform.
eBook
Poor Long-Term Efficacy of Prevnar-13 in Sickle Cell Disease Mice Is Associated with an Inability to Sustain Pneumococcal-Specific Antibody Titers
One of the most common causes of morbidity and mortality in children with sickle cell disease (SCD) is infection with the pneumococcal bacterium (Streptococcus pneumoniae). Unfortunately, the polysaccharide-conjugate vaccine appears to be less effective in individuals with SCD when compared to the general population. We sought to better understand the relative efficacy of pneumococcal vaccination in a SCD mouse challenge model.
Transgenic control and SCD mice were monitored for mortality after intranasal pneumococcal infection or pneumococcal vaccination with Prevnar-13 and type-matched challenge. Anti-pneumococcal antibody titers were measured by ELISA and opsonophagocytosis was measured in vitro.
Mortality after pneumococcal infection was similar between control and SCD mice. However, after three intramuscular polysaccharide-conjugate vaccinations, all control mice were protected following high-dose intranasal infection, whereas 60% of SCD mice died. Anti-pneumococcal antibody titers showed initial IgG and IgM responses in both groups, but waning titers were observed in the SCD group, even after boosting. When functionally assayed in vitro, serum from SCD mice 13 weeks after a second booster shot maintained little to no ability to opsonize pneumococci, while serum from control mice sustained a significantly higher capacity opsonization. Thus, it appears that SCD mice do not maintain antibody responses to pneumococcal polysaccharides after Prevnar-13 vaccination, thereby leaving them susceptible to mortality after type-matched infection.
Our results emphasize the need to better understand the correlates of immune protection in SCD so that pneumococcal vaccines can be improved and mortality reduced in this susceptible population.
Journal Article
Florida Torreya
The versatility of Mead’s milkweed, in terms of its geographical distribution and ability to grow in prairie habitat of varying soil types, contrasts starkly with the narrowly defined range and uncertain habitat requirements of Florida torreya (Torreya taxifolia), a rare conifer confined to the eastern banks of the Apalachicola River in Florida’s panhandle. In 1984 Florida torreya was listed as endangered under the Endangered Species Act, and it remains one of North America’s most endangered species of conifer. The IUCN considers it to be critically endangered, one step removed from the designation of extinct in the wild.
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Book Chapter
The cell
This volume examines the organization of various types of cells and provides an in-depth look at how cells operate alone to generate new cells and act as part of a larger network with others. --from publisher description
Book
Mead’s Milkweed
Historically, one of North America’s largest ecosystems was its native prairie, which cut a wide swath through the middle portion of the continent. It stretched from Alberta, Saskatchewan, and Manitoba in the north to Texas and the northern edge of Mexico in the south, and in the west it unfurled in a graceful descent at the eastern edge of the Rocky Mountains, cascading all the way to western Indiana. That vast expanse encompassed a staggering 400 million acres, and it included the entirety of the Great Plains. Within it could be found three distinct prairie types: tallgrass, mixedgrass, and shortgrass.
Book Chapter